ODCs

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3 OMIM references -
4 associated genes
12 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 3

1 OMIM reference -
1 associated gene
13 signs/symptoms

Juvenile amyotrophic lateral sclerosis

Autosomal recessive spastic paraplegia type 11

Citations in the biomedical literature:

Juvenile amyotrophic lateral sclerosis		Autosomal recessive spastic paraplegia type 11
	Synonym(s): - JALS - Juvenile Charcot disease - Juvenile Lou Gehrig disease		Synonym(s): - Nakamura-Osame syndrome - SPG11 - Spastic paraplegia - intellectual deficit - thin corpus callosum

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: adult Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: - Average age onset: - Average age of death: - Type of inheritance: autosomal recessive

	External references: 3 OMIM references - No MeSH references		External references: 1 OMIM reference - 2 MeSH references: C537483 / C538335


COMMON SIGNS	- Abnormal gait - Hypereflexia - Hypertonia / spasticity / rigidity / stiffness

Juvenile amyotrophic lateral sclerosis		Autosomal recessive spastic paraplegia type 11
	Very frequent - Abnormal EMG / electromyogram / electropmyography - Autosomal recessive inheritance - Elocution disorders / dysarthria / dysphonia - Motor deficit / trouble - Pyramidal syndrome Frequent - Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy - Pseudobulbar signs / spasmodic laugh and cry Occasional - Bladder and ureter anomalies - Sensitive trouble / deficit		Very frequent - Abnormal eye movements / oculomotor disorder - Ataxia / incoordination / trouble of the equilibrium - Corpus callosum / septum pellucidum total / partial agenesis - Cortical atrophy without hydrocephaly / cerebral hemiatrophy / subcortical atrophy - Dilated cerebral ventricles without hydrocephaly - Intellectual deficit / mental / psychomotor retardation / learning disability - Seizures / epilepsy / absences / spasms / status epilepticus - Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia Occasional - Areflexia / hyporeflexia - Functional anomalies of the nervous system